Endocrine Abstracts

Introduction Severe infection from the SARS-CoV-2 virus is associated with various manifestations, including hematological manifestations. Thrombotic events or a tendency to develop thrombotic events also characterize severe COVID-19 disease and may be related to fatalities. Vitamin D is known to have immunomodulating properties and to enhance the body defense system against invading pathogens and to have immunostimulatory properties as far as the innate immune response is con...

Morbid obesity is accompanied by multiple comorbidities and may be associated with a high mortality risk. Cardiac manifestations accompany morbid obesity and may account for the increased morbidity and mortality risk which accompanies the disorder. However, cardiac insufficiency as the first cardiovascular manifestation in morbid obesity is a less recognized comorbidity. The aim was to describe cardiac insufficiency as the first cardiovascular disease manifestation in morbid o...

Euthyroid sick syndrome also known as nonthyroidal illness syndrome is the reaction of the thyroid gland to severe disease. The SARS-CoV-2 virus affects the thyroid gland and may cause subacute thyroiditis, autoimmune Hashimoto’s thyroiditis, Graves’ disease, exacerbation of Graves’ disease and a form of silent thyroiditis. The aim was to study thyroid hormone levels and identify the presence of euthyroid sick syndrome in the context of severe SARS-CoV-2 disease...

Objectives: Triiodothyronine (LT3) administration for 48hours in patients undergone primary angioplasty showed favourable effects on cardiac function and remodelling early after myocardial infarction (Thy-Repair, EudraCT 2016-000631-40, Thyroid 2022 Jun;32(6):714-724). The present study investigated whether this beneficial effect was dependent on the severity of infarct size. The extent of infarct size is one of the main determinants of morbidity and mortality after myocardial...

BackgroundPheochromocytomas (PHOEs) and paragangliomas (PGLs) are rare neuroendocrine tumors originating from chromaffin cells. PHEO/PGL incidence ranges between 2–8/million, with 10–49% of these tumors being detected incidentally during imaging performed for other reasons. Up to 40% of PHEOs/PGLs patients have disease-specific germline pathogenic variants. This study aimed to investigate the epidemiology, clinical course, and genetic backgroun...

Background: Adipose tissue (AT) may have a significant role in obesity associated inflammation but, the mechanisms underlying the pathogenesis of obesity induced inflammation remains unclear. Recent murine studies indicate that ER stress is critical to the initiation and integration of inflammation and insulin signalling pathways. The ER stress occurs primarily due to accumulation of unfolded proteins and results in activation of the unfolded protein response to restore ER hom...

Background: Obesity is associated with chronic low-grade inflammation that contributes to the development of metabolic syndrome (MS). Resistin, produced by neutrophils and monocytes, displays potent proinflammatory properties and has been associated with cardiometabolic disease. The aim of this study was to (a) determine serum resistin levels among obese patients with or without MS and (b) explore the role of the subsets of circulating white blood cells as potential determinan...

Objective: Statins are the mainstay of treatment for patients with familial hypercholesterolaemia (FH). The purpose of this study was to systematically investigate and meta–analyze the best available evidence from randomized–controlled trials (RCTs) regarding the efficacy and safety of statins in children and adolescents with FH.Methods: A comprehensive search was conducted in PubMed, Scopus and Cochrane, up to July 10, 2019. Data were expres...

Background: The association between diabetes mellitus and diabetic nephropathy with vascular and endothelial properties is well-established. In this study, we compared the effect of combined treatment with dulaglutide and dapagliflozin versus DPP-4 inhibitors on endothelial glycocalyx, arterial stiffness, myocardial function and albuminuria in patients with type 2 diabetes mellitus and albuminuria.Methods: A total of 60 patients with type 2 diabetes mell...

Background: Neuroendocrine neoplasms (NENs) are rather uncommon while they have an incidence of no more than 0,5 per 100.000 people. The aim of this study is to investigate the prevalence of second neoplasms among patients diagnosed with sporadic NENs.Methods: Clinical and histological data from patients followed to our NENs clinic between 2020-2023 were retrospectively evaluated. Patients with a known genetic syndrome were excluded from the analysis.</p...